Analgesic activity of myricetin isolated from <Emphasis Type="Italic">Myrica rubra Sieb. et Zucc.</Emphasis> leaves |
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Authors: | Yan Tong Xiao-Mian Zhou Shu-Jun Wang Yang Yang Ying-Lin Cao |
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Institution: | (1) Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China;(2) Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR China;(3) Department of Pharmacology, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, PR China |
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Abstract: | Myrica rubra Sieb. et Zucc. leaves are commonly used as an astringent, antidiarrheic, and analgesics in folk medicine in China. In the present study,
the analgesic activity of myricetin, a major compound in Myrica rubra Sieb. et Zucc. leaves was evaluated in vivo. The analgesic effect of myricetin was tested by a serial of models, such as acetic acid-induced writhing response, formalin-induced
paw licking and hot plate test. The sedative activity was evaluated by pentobarbital-induced sleep time. Platelet aggregation
induced by collagen and arachidonic acid was also performed in vitro. Myricetin showed a significant inhibition on chemical nociceptive models such as the acetic acid-induced writhing response
and the licking time on the late phase in the formalin test in a dose-dependent manner, but did not manifest a signicant effect
in hot plate test. Myricetin was also not able to increase the sleeping time induced by pentobarbital, which further indicated
that the analgesic effect of myricetin was unrelated to sedation. In addition, myricetin inhibited the content of PGE2 in
the peritoneal fluid and platelet aggregation induced by collagen and arachidonic acid in vitro. These results collectively demonstrated that myricetin possessed potent analgesic activity, which was related with peripheral
analgesia, but, not with the opioid system. Myricetin may be a potent COX-1 inhibitor with anti-platelet activity. |
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Keywords: | Myrica rubra Sieb et Zucc Myricetin Analgesic activity |
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