| Ⅱ型糖尿病血浆PAI-1、t-PA检测的意义和结果评价 |
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| 引用本文： | 丁磊,夏文权,余文红,胡翊群. Ⅱ型糖尿病血浆PAI-1、t-PA检测的意义和结果评价[J]. 血栓与止血学, 2002, 8(1): 20-22,25 |
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| 作者姓名： | 丁磊 夏文权 余文红 胡翊群 |
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| 作者单位： | 上海第二医科大学附属瑞金医院检验系,上海,200025 |
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| 摘 要： | 目的:通过对Ⅱ型糖尿病患者分组(伴血管病变组、胰岛素抵抗组、胰岛素抵抗伴血管病变组、Ⅱ型糖尿病组)检测PAI-1、t-PA抗原及活性,并计算抗原比和活性比,以评价各检测指标的临床价值。方法:采用ELISA法检测PAI-1及t-PA抗原,采用发色底物法检测PAl-1、t-PA活性。结果:189例标本总体患病组及分组后各组的PAI-1活性、t-PA活性及t-PA活性/PAI-1活性比值与正常对照组比较均有显著性差异(P<0.05)。患病组间除t-PA抗原,其余检测显示胰岛素抵抗组、胰岛素抵抗组伴血管病变组与Ⅱ型糖尿病组存在显著性差异(P<0.05)。结论:在上述检测指标中t-PA活性、PAI-1活性反映血管病变的发生较敏感,t PA/PAI-1的活性比值更具临床应用价值。
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| 关 键 词： | 胰岛素抵抗 组织纤溶酶原激活物 Ⅰ型组织纤溶酶 原激活抑制物 临床意义 血管病变 Ⅱ型糖尿病 |
| 文章编号： | 1009-6213(2002)01-020-03 |
Estimate the Result of Measuring PAI-1 and t-PA in NIDDM |
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| DING Lei,XIA Wen-quan,YU Wen-hong,HU yi-qanShanghai Ruijin Hospital,Shanghai Second Medical University,Shanghai. Estimate the Result of Measuring PAI-1 and t-PA in NIDDM[J]. Chinese Journal of Thrombosis and Hemostasis, 2002, 8(1): 20-22,25 |
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| Authors: | DING Lei XIA Wen-quan YU Wen-hong HU yi-qanShanghai Ruijin Hospital Shanghai Second Medical University Shanghai |
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| Affiliation: | DING Lei,XIA Wen-quan,YU Wen-hong,HU yi-qanShanghai Ruijin Hospital,Shanghai Second Medical University,Shanghai 200015 |
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| Abstract: | Objective: To estimate the clinical application of antigen and activity of t-PA and PAI-1 . Methods: We studied 189 subjects of NIDDM and grouping(insulin resistance, coronary heart disease, insulin resistance with coronary heart disease, pure NIDDM), the concentrations and activities of t-PA and PAI-1 were measured using commercial kits. Results: There are differences between each NIDDM groups and normal group of activities of PAI-1 and t-PA, and also of the ratio of PAI-1 . Conclusion: The activities of PAI-1 and t-PA are more sensitivity in these index, and the ratios of t-PA/PAI-1 have more valve in clinical application |
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| Keywords: | Diabetes mellitus(DM) Insulin resistance Tissue plasminogen activator(t-PA) Plasminogen activator inhibitor-1(PAI-1) Ratio of t-PA/PAI |
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