参麦注射液对血液透析患者营养不良——炎症综合征的影响

目的 研究参麦注射液对维持性血液透析(maintenance hemodialysis，MHD)患者营养不良—炎症综合征(Malnutrition - inflammation Complex syndrom，MICS)的影响。

Effect of Shenmai Injection on Patients Suffering from Malnutrition-Inflammation Complex Syndrome during the Maintenance Hemodialysis

Objective To investigate the effect of Shenmai Injection （SMI） on patients undergoing maintenance hemodialysis （MHD） suffered from malnutrition-inflammation complex syndrome （MICS）. Methods Forty patients undergoing MHD were randomly allocated into two groups, the SMI group and the control group, 20 in each group. They were treated for three months. Blood levels of albumin （AIb）, high-sensitivityC-reactive protein （ hs-CRP）, interleukin 6 （IL-6） and interleukin 1β （IL-1β） as well as somatologic parameters were measured before and after treatment. Meantime, the modified subjective global analysis of nutrition （SGAN） was used to assess patients＇ nutritional status, and the quantitative scoring system was adopted to get the malnutrition score （MS）. Results In the SMI group after treatment, levels of MS, hs-CRP, IL-6 and IL-1β were lowered, levels of AIb, body weight, and SSF were increased significantly （ P 〈 0.05 or P 〈 0.01 ） ; as compared with those in the control group, MS, hs-CRP and IL-6 were lower, while SSF and AIb were higher （P〈0. 05 or P〈 0.01）. Levels of IL-6 and IL-1β, either in the SMI group or in the control group, were all higher than normal range （ P 〈 0.05）. Correlation analysis showed significant correlation presented between MS value with levels of AIb （P〈0.01） and IL-6 （P〈0.05）, also between IL-6 and AIb （P〈0.05）. Conclusion SMI can reduce the blood levels of hs-CRP, IL-6 and IL-1β in patients undergoing MHD, improve their nutritional indices, suggesting that it could alleviate the MICS in these patients.