| 611例汉族人维生素D受体基因多态性与骨密度关系研究 |
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| 引用本文： | 缪应新 朱汉民 朱晓颖. 611例汉族人维生素D受体基因多态性与骨密度关系研究[J]. 中华内分泌代谢杂志, 2005, 21(5): 448-449 |
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| 作者姓名： | 缪应新 朱汉民 朱晓颖 |
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| 作者单位： | 上海市华东医院老年研究所 200040(缪应新，朱汉民)，上海市华东医院老年研究所 200040(朱晓颖) |
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| 摘 要： | 采用PCR-RFLP分析了611名上海地区汉族人的维生素D受体(VDR)基因型,并测量其骨密度(BMD),统计分析发现男女性VDR基因分布差异存在统计学意义,Bb基因型在男性中的分布频率(26.9%)高于女性(12.7%,P<0.01)。不同基因型的人群BMD差异无统计学意义。
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| 关 键 词： | 骨质疏松 受体 骨化三醇 多态现象(遗传学) 骨密度 |
| 收稿时间： | 2004-03-11 |
| 修稿时间： | 2004-03-11 |
Relationship between bone mineral density and polymorphism of vitamin D receptor gene in 611 Hans |
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| MIAO Ying-xin, ZHU Han-min, ZHU Xiao-ying. Relationship between bone mineral density and polymorphism of vitamin D receptor gene in 611 Hans[J]. Chinese Journal of Endocrinology and Metabolism, 2005, 21(5): 448-449 |
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| Authors: | MIAO Ying-xin ZHU Han-min ZHU Xiao-ying |
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| Affiliation: | Shanghai Institute of Geriatrics, Huadong Hospital, Shanghai 200040 |
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| Abstract: | Vitamin D receptor (VDR) genotypes and bone mineral density (BMD) of 611 subjects in Shanghai were investigated. The results indicated that the frequency of Bb genotype in male is higher than that in female (26.9% vs 12.7%, P<0.01), and there was no significant difference in BMD between different genotype-groups. |
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| Keywords: | Osteoporosis Receptors calcitriol Polymorphism (Genetics) Bone density |
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