| 不同炮制方法对川乌双酯型生物碱含量的影响 |
| |
| 引用本文： | 梁泽华,尹丽娜,杨燕,熊耀康.不同炮制方法对川乌双酯型生物碱含量的影响[J].中国现代应用药学,2009,26(4):288-291. |
| |
| 作者姓名： | 梁泽华 尹丽娜 杨燕 熊耀康 |
| |
| 作者单位： | 1.浙江中医药大学，杭州 310053；2.浙江省医学科学院，杭州 310013 |
| |
| 基金项目： | 浙江省中医药管理局（2006C001）和浙江中医药大学校级重点（1710052）资助项目 |
| |
| 摘 要： | 目的 研究炮制方法对川乌双酯型生物碱含量的影响。方法将生川乌分别通过药典法、黑豆法和米醋法进行炮制，以RP—HPLC结合梯度洗脱的色谱方法为检测手段，比较分析不同川乌炮制方法对双酯型生物碱（主要为乌头碱、次乌头碱）含量的影响。结果3种炮制方法均可显著降低生川乌中乌头碱、次乌头碱的含量。所建立的色谱方法可定量分析炮制品中双酯型生物碱。结论不同炮制方法对生川乌均能起到减毒作用。
|
| 关 键 词： | 川乌 炮制方法 双酯型生物碱 高效液相色谱法 梯度洗脱 |
| 收稿时间： | 1/1/1900 12:00:00 AM |
The Effect of the Processing Methods on the Content of Diacrylate Alkaloids of Radix Aconiti |
| |
| LIANG Zehu,YIN Lin,YANG yan,XIONG Yaokang.The Effect of the Processing Methods on the Content of Diacrylate Alkaloids of Radix Aconiti[J].The Chinese Journal of Modern Applied Pharmacy,2009,26(4):288-291. |
| |
| Authors: | LIANG Zehu YIN Lin YANG yan XIONG Yaokang |
| |
| Institution: | 1.Zhejiang Chinese Medical University, Hangzhou 310053,China;2.Zhejiang Academy of Medical Sciences, Hangzhou 310013,China |
| |
| Abstract: | OBJECTIVE To study the effect of the processing methods on the content of diacrylate alkaloids of Radix Aconiti （RA）. METHODS The RA was processed,using Ch. P,Black Bean and Vinegar law metheds. RPHPLC with gradient elution was established for determining the content of diacrylate alkaloids（mainly aconitine,hypaconitine）. RESULTS Three processing methods can significantly reduce the contents of aconitine and hypaconitine. Chromatographic methods established can be applied to the quantitative analysis of the diacrylate alkaloids of processed products. CONCLUSION The described processing methods can reduce the content of diacrylate alkaloids of RA. |
| |
| Keywords: | Polygonum flaccidum Messin volatile constituent GC/MS |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
| 点击此处可从《中国现代应用药学》下载免费的PDF全文 |
