| 吗啡戒断大鼠脊髓和脑干以及前脑皮层胶质细胞源性神经营养 … |
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| 引用本文： | 周文华,刘惠芬.吗啡戒断大鼠脊髓和脑干以及前脑皮层胶质细胞源性神经营养 …[J].中华医学杂志,2000,80(2):135-139. |
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| 作者姓名： | 周文华 刘惠芬 |
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| 基金项目： | 浙江省医药卫生科研基金!( 98A0 93 ) |
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| 摘 要： | 观察吗啡依赖或戒断时大鼠脊髓，脑干和皮层胶质细胞源性神经营养因子（ｇｉａｌｃｅｌｌ ｄｅｒｉｖｅｄ ｎｅｕｒｏｔｒｏｐｈｉｃ ｆａｃｔｏｒ，ＧＤＮＦ）以及受体ＧＤＮＦＲ－α和ＧＤＮＦＲ－β基因的表达以及毒蕈碱乙酰胆碱受体（ｍＡｃｈ）、Ｎ－甲基－Ｄ－天门冬氨酸（ＮＭＤＡ）受体拮抗或一氧化氮合酶（ＮＯＳ）抑制剂处理后对它们合酶链反应（ＲＴ－ＰＣＲ），以β－ａｃｔｉｎｍＲＮＡ作为内标检测ＧＤＮＦ，ＧＤＮ
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| 关 键 词： | 吗啡依赖 受体 神经递质 基因表达 mRNA |
| 修稿时间： | 1999-02-04 |
The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats] |
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| W Zhou,H Liu,X Xie.The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats][J].National Medical Journal of China,2000,80(2):135-139. |
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| Authors: | W Zhou H Liu X Xie |
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| Institution: | Ningbo Institute of Microcirculation & Henbane, Ningbo Drug Addiction Research and Treatment Center, Ningbo 315010, China. |
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| Abstract: | |
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| Keywords: | Addiction morphine Receptor neurotransmitter Gene expression |
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