1 094株革兰阴性杆菌的耐药性分析

目的了解革兰阴性杆菌的耐药状况,为临床用药提供参考依据。方法采用Kirby-Baure纸片扩散法,对1094株革兰阴性杆菌进行药物敏感性监测。结果1094株革兰阴性杆菌对亚胺培南、美洛培南、头孢哌酮-舒巴坦、哌拉西林-他唑巴坦敏感率依次为88.9%,87.8%,86.1%,85.0%,头孢噻吩的敏感率最低为15.2%,26.7%的大肠埃希菌和30.8%的肺炎克雷伯菌产超广谱β-内酰胺酶。结论革兰阴性杆菌除对亚胺培南、美洛培南、头孢哌酮-舒巴坦、哌拉西林-他唑巴坦有较低的抗菌活性外,对氨基糖甙类(阿米卡星,庆大霉素)、喹诺酮类(环丙沙星,左旋氧氟沙星),头孢类(一、二、三、四代)的药物均有较高的抗药性,多重耐药性细菌成为临床的主要感染菌。

Analysis on Resistance against Drugs of 1 094 Strains of Gram Negative Bacilli

Objective To realize the drug resistance of Gram negative bacilli so as to provide the reference and the foundation for clinical application of drugs. MethodsDrug susceptibilities were tested in 1094 strains of Gram negative bacilli by Kirby-Baure disc diffusion. ResultsThe drug susceptibilities of the Gram negative bacilli were 88.9% (to imipenem), 87.8% (to meropenem), 86.1% (to cefoperazone/sulbactam), 85.0% (to piperacillin/tazobactam) in succession, and the lowest susceptibility was 15.2% (to cefalotin). Furthermore, super-broad spectral β-lactamase was found in 26.7% of Escherichia coli and 30.8% of Klebsiella pneumoniae. ConclusionGram negative bacilli possess low drug resistance against imipenem, meropenem, cefoperazone/sulbactam and piperacillin/tazobactam, and high drug resistance against aminoglycosides (amikacin, gentamycin), and quinolones (ciprofloxacin, levofoxacin) and some cephalosporins.