I类切口手术围手术期预防性使用抗菌药物干预前后的对比分析

目的浅析干预前后I类切口手术围手术期预防性应用抗菌药物的使用状况，探索抗菌药物使用合理性及干预模式的效果。方法随机抽取自2011年3月_2011年9月该院行I类切口手术围手术期病患158例作为干预前组，另选择2012年3月-2012年9月的I类切口手术围手术期病患164例作为干预后组，对所有患者预防性实施抗菌药物的种类、使用频数、复合用药情况做详细阐述，并进行统计研究和对照分析。结果干预后组头孢类药物使用频率由36．71％下降到17．68％，青霉素类、糖肽类、硝咪唑类药物变化不大，克林霉素则由3．80％降至为0。复合用药情况及不合理用药形势等方面用药规范性显著提高，差异有统计学意义（P〈0．05）。结论健全的干预性治疗可显著减少抗菌药物不规范性，用药合理性临床有较大提升空间，需相关医师加强监督管理。

Contrastive Analysis on the Previous or Post Usage of Antibacterial Drug Intervention of I Type Incision Perioperative Period

Objective To analyze the previous or post usage of antibacterial drug intervention of I type incision perioperative period, and to explore the usage reasonability and effect of intervening mode of antibacterial drug. Methods 158 patients of I type incision periop erative period admitted to our hospital from March 2011 to September 2011 were randomly selected as prevention group, and another 164 patients of I type incision perioperative period admitted to our hospital from March 2011 to September 2011 were randomly selected as post prevention group. All the patients＇ preventive conduction types of antibacterial drug,usage frequency, compound meditation were il lustrated in detail. Then it was conducted with statistical research and contrastive analysis. Results In post intervention group,the usage frequency of eephalosporins declined from 36.71% to 17.68%. And penicillin, sugar peptide, imidazoles nitrate drugs did not change much, while clindamycin declined from 3.80% to 0. Some normative pharmacy like compound meditation and unreasonable pharmacy im proved remarkably. And the result is of statistical significance with the value of p less than 0.05. Conclusions The comprehensive pre ventive therapy can reduce the nonstandard antibacterial drug, and there is much potential space for the reasonable pharmacy clinic to im prove, which requires relevant doctors to strengthen supervision and management.