氯吡格雷对急性ST段抬高心肌梗死溶栓的疗效和安全性

目的研究常规溶栓联合氯吡格雷治疗急性ST段抬高心肌梗死患者的疗效和安全性。方法随机选择2005年1月至2007年12月于栾川县人民医院住院的急性ST段抬高心肌梗死发病6h以内患者90例，其中联合氯吡格雷治疗者（氯吡格雷组）48例，未联合氟吡格雷者（对照组）42例。观察两组主要疗效和安全性指标。结果氯吡格雷组较对照组具有较高的血管再通率（分别为68．8％、50．0％，P〈0．05），主要不良心脏事件发生率降低（分别为4．2％、14．3％，P〈0．05），出血发生率与对照组比较差异无统计学意义（分别为8．3％、9．5％，P〉0．05）。结论溶栓联合氯吡格雷治疗急性ST段抬高心肌梗死患者是安全有效的：

Efficacy and safety of fibrinolytic therapy plus clopidogrel for patients with acute ST-segment elevation myocardial infarction

Objective To observe the efficacy and safety of addition of clopidogrel to fibrinolytic therapy for acute ST-segment elevation myocardial infarction. Methods Patients underwent acute ST-segment elevation myocardial infarction within 6 hours were recruited in the people's hospital of luanchuan county from January 2005 to December 2007. Patients (n=90) were allocated into 2 groups,one group received clopidogrel (n=48),the other group didn't receive clopidogrel (n=42). The main indicators of efficacy and safet...