Toxicity of trimetrexate on hemopoietic progenitor cells in normal mice |
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| Authors: | G V Bogliolo R A Lerza M P Mencoboni A G Saviane I M Pannacciulli |
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| Affiliation: | Patologia Speciale Medica B, University of Genoa, Italy. |
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| Abstract: | Single increasing doses of methotrexate (MTX) and trimetrexate (TMQ) were administered to normal mice. Survival of hemopoietic progenitor cells assayed as CFU-S and GM-CFC was determined 24 hr after drug injection. The survival of each population in TMQ-treated animals was not statistically different from that observed in mice treated with MTX. No difference was observed in time-survival curves of hemopoietic progenitor cells comparing TMQ to MTX. TMQ toxicity at the hematological level thus seems comparable to that of MTX. |
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