荷瘤小鼠免疫器官及免疫功能的研究

荷瘤小鼠胸腺和脾脏的重量均低于正常小鼠，俞至晚期差别俞明显（Ｐ＜００１，Ｐ＜００５），而病毒免疫疗法治愈鼠的胸腺和脾脏的重量则恢复至正常水平，自然杀伤细胞功能和腹腔巨噬细胞的数量也与小鼠荷瘤时间密切相关，植入瘤细胞后第６天自然杀伤细胞功能开始低于正常小鼠，第１６天仅为８％，而巨噬细胞数量则从第３天开始迅速下降，第１０天仅为０．０６×１０４／只，明显低于第１天的３３．４０×１０４／只。以上研究提示，对荷瘤小鼠的病毒免疫治疗应在荷瘤早期进行，到了晚期，因细胞免疫功能低下，此时再进行肿瘤的病毒免疫治疗不会取得好效果。

Study on immune organs and immune function in tumor-bearing mice

The weights of spleen and thymus in tumor-bearing mice were lower than that in normal mice and were entirely restored by viral immunotherapy. The function of natural killer cells(NKC)and the number of celiac macrophages were related with tumor-bearing time, too. The function of NKC in tumor-bearing mice began to be lower than that in contral mice after six days of transplanting S180 ascitic tumor.The kill rate of NKC was only 8%after sixteen days.The number of macrophages began to decrease rapidly after three days and was only 0.06×104/mouse after ten days,which was obviously lower than 33.4×104 /mouse in first day.The results show that the viral immunotherapy for tumorbearing mice should be early taken,or the therapeutic effect will be poor because the cellular immune function is lower.