Evaluation of the teratogenic potential and reproductive toxicity of coal-derived naphtha |
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| Authors: | R H McKee J P Hinz K A Traul |
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| Affiliation: | 1. Faculty of Medicine, Department of Medical Pharmacology, Bilecik Şeyh Edebali University, Bilecik 11230, Turkey;2. Faculty of Medicine, Department of Physiology, Erzincan Binali Yildirim University, Erzincan 24100, Turkey;3. Faculty of Medicine, Department of Medical Pharmacology, Malatya Turgut Ozal University, Malatya 44210, Turkey;4. Faculty of Arts and Sciences, Department of Biology, Erzincan Binali Yildirim University, Erzincan 24100, Turkey;5. Faculty of Medicine, Department of Medical Pharmacology, Ataturk University, Erzurum 25240, Turkey;6. Faculty of Veterinary, Department of Pathology, Ataturk University, Erzurum 25240, Turkey;7. Histology and Microscopic Analysis division, RASTA Specialized Research Institute (RSRI), West Azerbaijan Science and Technology Park (WASTP), Urmia, Islamic Republic of Iran;8. Department of Urology, Ioannina University School of Medicine, Ioannina, Greece;9. Department of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece;10. Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Medical School, Heraklion, Crete, Greece;1. Division of Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;2. Thermochemical Energy Conversion Laboratory, Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden;3. Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden;4. Department of Ergonomics and Aerosol Technology, Lund University, Lund, Sweden |
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| Abstract: | Liquids which are derived from coal liquefaction processes and boil above approximately 250 degrees C have induced terata in rats. However, few studies have addressed the teratogenic potential of coal liquids which boil below 250 degrees C. The present studies evaluated the reproductive and teratogenic potential of EDS hydrotreated naphtha, a refined coal liquid boiling below 177 degrees C. These studies were conducted by inhalation exposures with Sprague-Dawley rats at target vapor concentrations of 0.2, 1.0, and 5.0 g/m3. The first study assessed teratogenesis. There was no evidence that inhalation exposures for 6 hr per day between Days 6 and 19 of gestation induced maternal toxicity, fetal toxicity, or malformation. In a second study, rats were exposed for 6 hr per day, 5 days per week for 13 weeks, and then mated to assess reproductive toxicity. There was little evidence that inhalation exposure to EDS hydrotreated naphtha adversely affected reproductive performance or fetal development in Sprague-Dawley rats. A low incidence of malformations was observed in treated groups, but these malformations were probably not treatment related. |
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