Giant multivesicular bodies in the rat hippocampal pyramidal cells after chronic alcohol consumption |
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| Authors: | M M Paula-Barbosa M M Borges A Cadete-Leite M A Tavares |
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| Affiliation: | 1. Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands;2. Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands;3. BioImaging Facility, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands;4. Division of Cell Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands |
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| Abstract: | Multivesicular bodies (MVBs) with diameters up to 4.5 microns were observed in the hippocampal pyramidal cells of rats submitted to chronic alcohol consumption. A significant increase in the volumetric density (Vv) of these organelles was found in CA1 pyramidal cells. Transitional forms of MVBs towards lysosomes were seen. A failure in MVB's enzymatic hydrolytic mechanisms, due to the prolonged alcohol aggression, could underlie its formation. |
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