| 2-氯-4-氨基-6,7-二甲氧基喹唑啉的合成 |
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| 引用本文： | 王功霞,张岱州,曲庆美. 2-氯-4-氨基-6,7-二甲氧基喹唑啉的合成[J]. 齐鲁药事, 2006, 25(9): 550-551 |
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| 作者姓名： | 王功霞 张岱州 曲庆美 |
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| 作者单位： | 1. 山东省医药工业研究所,济南,250100
2. 山东药品食品职业学院,威海,264210 |
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| 摘 要： | 目的合成2-氯-4-氨基-6,7-二甲氧基喹唑啉。方法以香草醛为原料,经甲基化、硝化、氧化、还原、环合、氯化、胺化等反应制得目标化合物。结果及结论该实验方法总收率26%,反应条件温和,操作简便,适合工业化生产。
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| 关 键 词： | 2-氯-4-氨基-6 7-二甲氧基喹唑啉合成 |
| 文章编号： | 1672-7738(2006)09-0550-02 |
Synthesis of 2-chloro-4-amino-6,7-dimethoxyquinazoline |
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| WANG Gong-xia,ZHANG Dai-zhou,QU Qing-mei. Synthesis of 2-chloro-4-amino-6,7-dimethoxyquinazoline[J]. qilu pharmaceutical affairs, 2006, 25(9): 550-551 |
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| Authors: | WANG Gong-xia ZHANG Dai-zhou QU Qing-mei |
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| Abstract: | OBJECTIVE To synthesize 2-chloro-4-amino-6,7-dimethoxyquinazoline.METHODS Vanillin was used as the raw material to prepare the final product by methylation,nitration,oxidation,reduction,cyclization,chlorination,amination.RESULTS and CONCLUSION The overall yield was 26%.The reaction condition was mild,easy to operate.Adapted to industrialization production. |
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| Keywords: | 2-chloro-4-amino-6 7-dimethoxyquinazoline synthesis |
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