| 门冬氨酸钾镁的保肝和退黄疸作用 |
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| 引用本文： | 章蕴毅,李佩芬. 门冬氨酸钾镁的保肝和退黄疸作用[J]. 中国实用医药, 2008, 3(28): 13-14 |
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| 作者姓名： | 章蕴毅 李佩芬 |
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| 作者单位： | 复旦大学药学院药理教研室,上海,200032 |
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| 摘 要： | 目的观察门冬氨酸钾镁对D-氨基半乳糖和异硫氰酸-1-萘酯（ANIT）引起的大鼠肝损伤的保护作用。方法大鼠预先给予门冬氨酸钾镁5d后,注射D-氨基半乳糖和异硫氰酸-1-萘酯,观察肝脏受损后血清天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、胆红素的水平,并进行病理切片检查。结果门冬氨酸钾镁2、4ml/kg可以显著降低由D-氨基半乳糖引起的AST以及ANIT引起的血清总胆红素升高。结论门冬氨酸钾镁可以拮抗D-氨基半乳糖和ANIT引起的肝损伤,有一定的保肝作用。
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| 关 键 词： | 门冬氨酸钾镁 肝损伤 D-氨基半乳糖 异硫氰酸萘酯 |
The hepatic protection and biliary lowering effects of potassium magnesium aspartate |
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| ZHANG Yun-yi,LI Pei-fen. The hepatic protection and biliary lowering effects of potassium magnesium aspartate[J]. China Practical Medical, 2008, 3(28): 13-14 |
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| Authors: | ZHANG Yun-yi LI Pei-fen |
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| Affiliation: | ZHANG Yun-yi,LI Pei-fen.Department of Pharmacology,School of Pharmacy,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective To study the protective effect on the hepatic damage induced by D-Galactosamine and 1-naphthyl isothiocyanate.Methods Rats were orally given potassium magnesium aspartate for 5 days.Then rats were treated with D-Galactosamine or 1-naphthyl isothiocyanate.The serum AST,ALT and bilirubin were tested.Results 2 and 4 ml/kg potassium magnesium aspartate decreased the high AST level which induced by D-galactosamine and serum total biliary induced by 1-naphthyl isothiocyanate.Conclusion Potassium magnesium aspartate had the protective effects against the hepatic damage caused by D-galactosamine and 1-naphthyl isothiocyanate. |
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| Keywords: | Potassium magnesium aspartate Liver damage D-Galactosamine 1-naphthyl isothiocyanate |
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