血浆纤维蛋白原与急性心梗及其危险因素的关系

【目的】观察和探讨急性心梗（AMI）患者血浆纤维蛋白原水平的变化与AMI及其危险因素的关系。【方法】采用凝血酶法测定300例AMI患者及300例健康对照者的血浆纤维蛋白原水平。【结果】AMI组患者血浆纤维蛋白原水平明显高于健康对照组（P〈0．01）。AMI患者血浆纤维蛋白原水平与性别、族别（汉族、维吾尔族）比较无统计学差异。AMI患者中高脂血症者的血浆纤维蛋白原水平与甘油三酯（r=0．862，P〈0．01）、低密度脂蛋白胆固醇（r=0．625，P〈0．05）及高密度脂蛋白胆固醇（r=-0．861，P〈0．01）有很强的相关性。AMI患者中其他危险因素与纤维蛋白原水平的关系为：吸烟者的纤维蛋白原水平明显高于不吸烟者（P〈0．01）；高龄组的纤维蛋白原水平明显高于低龄组（P〈0．05）；合并糖尿病患者纤维蛋白原水平明显高于无合并糖尿病者（P〈0．05）；合并高血压患者与无合并高血压患者的纤维蛋白原水平比较无统计学差异。【结论】血浆纤维蛋白原水平增高是一个主要的AMI危险因素，有效降低血浆纤维蛋白原水平对预防和治疗AMI是至关重要的。

Study on the Correlation between plasma fibrinogen acute myocardial infarctionand the its risk factors

Objective] To investigate the relationship between plasma fibrinogen （Fg） and the risk factors of acute myocardial infarction. Methods] Plasma fibrinogen were measured in 300 patients with acute myocardial infarction and 300 normalsubjects. Results] The level of plasma fibrinogen in patients with acute myocardial infarction was higher than that in the normal subject （P 〈 0.01 ）. There were no significant differences between Han and Uighur. The level of plasma fibrinogen in patients with cigarette smoking was higher than non smoking subsect （P 〈 0.05）. The level of pldsma fibrinogen in younger （ 〈 60 years） was lower than that in elder （ 〉 60 years） （P 〈 0.05）. There was significant differenc in patients combined with diabetes mellitus or lipid disorder than those without diabetes mellituso or lipid disor der. Conclusions] The results suggest that high plasma fibrinogen is a major risk factor in coronary heart disease. It is important in decreasing the level of plasma tibrinogen in the treatment and prevention of coronary heart disease.