| TP与NP方案治疗晚期非小细胞肺癌的临床对照研究 |
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| 引用本文： | 卞宝祥,宋子琰,杨成喜,胡楠,吉亚君. TP与NP方案治疗晚期非小细胞肺癌的临床对照研究[J]. 肿瘤基础与临床, 2008, 21(6) |
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| 作者姓名： | 卞宝祥 宋子琰 杨成喜 胡楠 吉亚君 |
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| 作者单位： | 连云港市第一人民医院肿瘤科,江苏,连云港,222002;连云港市第一人民医院肿瘤科,江苏,连云港,222002;连云港市第一人民医院肿瘤科,江苏,连云港,222002;连云港市第一人民医院肿瘤科,江苏,连云港,222002;连云港市第一人民医院肿瘤科,江苏,连云港,222002 |
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| 摘 要： | 目的 评价艾素(国产多西紫杉醇)+顺铂与盖诺(国产诺维本)+顺铂方案治疗晚期非小细胞肺癌的疗效、毒副反应.方法 29例予TP方案:多西紫杉醇75 mg/m2,静脉滴注,第1天;DDP 30 mg/m2,静脉滴注,第1～3天.35例予NP方案:NVB 25 mg/m2,静脉滴注,第1、8天;DDP 30 mg/m2,静脉滴注,第1～3天.每28 d为1周期,观察疗效和毒副反应.结果 TP方案有效率为44.83%,NP方案有效率为40.00%,两组疗效相似(P=0.90).TP组和NP组的中位生存期分别为11.25和10.47个月,1年生存率分别为37.93%和40.00%(P=0.93).最常见毒副反应为骨髓抑制,TP组Ⅲ～Ⅳ白细胞减少17.24%,NP组为22.86% (P=0.81).结论 TP方案和NP方案均有较佳疗效,两方案疗效无显著差异,毒副反应均可耐受.
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| 关 键 词： | 晚期非小细胞肺癌 多西紫杉醇 诺维本 顺铂 |
A Comparative Study of TP and NP Combined with Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer |
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| Bian Baoxiang,Song Ziyan,Yang Chengxi,Hu Nan,Ji Yajun. A Comparative Study of TP and NP Combined with Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer[J]. Journal of Basic and Clinical Oncology, 2008, 21(6) |
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| Authors: | Bian Baoxiang Song Ziyan Yang Chengxi Hu Nan Ji Yajun |
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| Affiliation: | Bian Baoxiang,Song Ziyan,Yang Chengxi,Hu Nan,Ji Yajun(Department of Oncology,Lianyungang 1st Hospital,Lianyungang 222002,China) |
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| Abstract: | Objective To compare the efficacy and adverse effects between docetaxel plus cisplatin with vinorelbine plus cisplatin in the treatment of advanced NSCLC.Methods 29 patients received docetaxel 75 mg/m2 on day 1,plus cisplatin 30 mg/m2 on days 1-3;35 patients received vinorelbine 25 mg/m2 on days 1,8 plus cisplatin 30 mg/m2 on days 1-3.Every 28 days as a cycle to observe the efficacy and adverse effects.Results The objective response rate was 44.83% in TP group,compared with 40.00% in NP group(P=0.90).Median... |
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| Keywords: | non-small cell lung cancer docetaxel vinorelbine cisplatin |
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