参芪扶正注射液对胃癌患者手术及化疗时免疫功能的影响

目的探讨参芪扶正注射液对胃癌患者手术及化疗时免疫功能的影响。方法对123例胃癌术后及36例胃癌化疗患者，根据静脉注射参芪扶正注射液与否，分别检测红细胞C3b受体花环(RBC-C3bRR)、免疫复合物花环(RBC-ICR)、T细胞亚群以及NK细胞活性。结果胃癌患者术后合并应用参芪扶正组较单纯术后组RBC-C3bRR、CD3、CD4、NK细胞活性显著升高，RBC-ICR显著降低(P＜0.01)；胃癌患者化疗合并应用参芪扶正组较单纯化疗组RBC-C3bRR、CD3、CD4、NK细胞活性显著升高，RBC-ICR显著降低(P＜0.01)。结论胃癌患者手术后和化疗时合并应用参芪扶正注射液可明显改善免疫功能。

Effect of Shenqi Fuzheng Injection on Immune Function in Gastric Carcinoma Patients in Post-Operational and Chemotherapeutic Period

Objective: To investigate the effect of Shenqi Fuzheng injection (SQFZI) on immune function in gastric carcinoma patients in post operational and chemotherapeutic period. Methods: One hundred and twenty three gastric carcinoma post operational patients and 36 cases of gastric carcinoma patients on chemotherapy, according to their using SQFZI or not, parameters of immune function, including red blood cell C3b receptor rosette (RBC C3bRR) and immune complex rosette (RBC ICR), T lymphocyte subsets and NK cell activity were determined. Results: RBC C3bRR, CD 3, CD 4 and NK cell activity were significantly higher, but RBC ICR was lower in patients of post operational period treated with SQFZI than those in patients untreated with SQFZI (P<0 01). The same difference also revealed between the patients in chemotherapeutic period treated and untreated with SQFZI (P<0 01). Conclusion: The immune function of gastric carcinoma patients in post operational or chemotherapeutic period could be effectively improved by addition of SQFZI.