Pregnancy associated plasma protein-A (PAPP-A) is not a marker of the vulnerable atherosclerotic plaque |
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| Authors: | Iversen Kasper Teisner Ane Dalager Soren Olsen Karen Ege Floridon Charlotte Teisner Børge |
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| Affiliation: | aDepartment of Cardiology, Hillerod Hospital, Hillerod, Denmark;bDepartment of Internal Medicine, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark;cInstitute of Pathology, Aarhus University Hospital, Aarhus, Denmark;dDepartment of Pathology, Odense University Hospital, Odense, Denmark;eDepartment of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark;fImmunology and Microbiology, University of Southern Denmark, Denmark |
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| Abstract: | ObjectiveTo investigate if pregnancy associated plasma protein-A (PAPP-A) was present in the vulnerable plaque, and if not, to find alternative hypothesis for the release of PAPP-A.Design and methodsVulnerable plaques and control tissues were examined by immunohistochemistry. Volunteers and patients with non-atherosclerotic disease were examined for release of PAPP-A during ischemia and medical treatment. Non-atherosclerotic tissue samples were examined after incubation with heparins.ResultsWe were not able to detect PAPP-A in vulnerable plaques. Patients and volunteers experiencing ischemic events without atherosclerotic lesions only had elevated PAPP-A when treated with heparin. When tissue from normal artery wall was incubated with heparin, PAPP-A was eluted. This was not the case for non-arterial tissue samples.ConclusionElevation of PAPP-A in patients with acute coronary syndromes seems to be caused by heparin induced release of PAPP-A from the arterial wall and not due to excretion from vulnerable plaques. |
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| Keywords: | Abbreviation: PAPP-A Pregnancy associated plasma protein-A |
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