Increased serum levels of S100B are related to the severity of cardiac dysfunction, renal insufficiency and major cardiac events in patients with chronic heart failure |
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Authors: | Li Jin Ping Lu Lin Wang Ling Jie Zhang Feng Ru Shen Wei Feng |
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Affiliation: | aDepartment of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, PR China;bInstitute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China |
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Abstract: | ObjectiveTo investigate the correlations between S100B and the severity of cardiac dysfunction, renal insufficiency (RI) and prognosis in chronic heart failure (CHF).MethodSerum levels of S100B, TNF-α, high sensitivity CRP and NT-proBNP were determined in CHF patients with (n = 96) and without RI (n = 146). Patients with RI only (n = 62) and control subjects (n = 64) served for comparison. Patients were followed up for one year.ResultsS100B levels were higher in CHF patients with a further elevation in those with RI (P < 0.01). Serum S100B levels correlated with left ventricular ejection fraction, left ventricular end-diastolic volume and NT-proBNP in CHF patients, and eGFR in patients with RI (all P < 0.05). Increased S100B levels were associated with major cardiac events (MCE), and were independently associated with the presence of CHF (all P < 0.05).ConclusionIncreased serum S100B levels were associated with the severity of cardiac dysfunction, RI and an adverse prognosis in CHF patients. It represents an independent risk factor for CHF. |
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Keywords: | Heart failure Renal insufficiency S100B protein |
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