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Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV-HBV co-infected patients
Authors:Khodadadi Iraj  Abdi Mohammad  Ahmadi Abbas  Wahedi Mohammad Saleh  Menbari Shahoo  Lahoorpour Fariba  Rahbari Rezgar
Affiliation:aDepartment of Biochemistry and Nutrition, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran;bDepartment of Pathology and Medical Laboratory Sciences, Faculty of Para Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;cDepartment of Hematology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;dDepartment of Anesthesia, Faculty of Para Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;eDepartment of Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:

Objectives

To determine adenosine deaminase (ADA) activity as a possible diagnostic marker in HIV and HIV–HBV co-infected patients.

Design and methods

Blood samples were collected from 72 healthy, 33 HIV positive and 30 HIV–HBV co-infected subjects. Blood CD4+ cell count was recorded and serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total ADA, and ADA1 and ADA2 isoenzyme activities were determined.

Results

Serum ALT, AST, total ADA and ADA2 isoenzyme activities were significantly higher in HIV positive and HIV–HBV co-infected groups compare to the control (p < 0.05), whereas serum ALP showed no differences between groups. CD4+ cell counts markedly decreased in all patients and showed a significant inverse correlation with ADA activities (R2 = 0.589, p < 0.001).

Conclusions

Serum ADA was significantly increased in HIV and HIV–HBV co-infections. Therefore, because of its low cost and simplicity to perform, ADA activity might be considered as a useful diagnostic tool among the other markers in these diseases.
Keywords:Adenosine deaminase   Isoenzymes   Human immunodeficiency virus   Hepatitis B virus
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