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Acute renal failure due to severe Landry-Guillain-Barre syndrome
Authors:Khajehdehi, P   Shariat, A   Nikseresht, A
Affiliation:Intensive Care Unit, Department of Internal Medicine, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author at: House 53, Lane 10-Jangali, Mirza-Kouchak-Khan-Jangali Highway (Ardekan Road), 71959, Shiraz, Iran
Abstract:Background: Blood urea nitrogen (BUN) >60 mg/dlhas been reported to occur commonly in patient's with severeLandry-Guillain-Barré syndrome. Aims: Tofind out the cause for this high BUN we compared the renal function testsof 30 consecutive cases with severe Landry-Guillain-Barrésyndrome to those of 30 controls. Results: Acute renalfailure occurred in seven patients with Landry-Guillain-Barrésyndrome and one of the control group. Acute renal failure was found morein cases with Landry-Guillain-Barré syndrome compared tocontrols (P=0.0049). Six out of seven cases withLandry-Guillain-Barré syndrome and acute renal failure haddysautonomia and became oliguric while being in a hypotensive state. Of 30patients with Landry-Guillain-Barré syndrome seven cases died.From eight patients with dysautonomia six cases who had acute renal failuredied. The mortality rate was higher in cases with dysautonomia and acuterenal failure (P=0.0001 and 0.00001, respectively). Interestingly noglomerular disease was found. Conclusion: Inconclusion acute renal failure can occur commonly in cases with severeLandry-Guillain-Barré syndrome particularly in those withdysautonomia, causing high mortality.
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