补充维生素A对接种麻疹疫苗的学龄儿童IgG抗体水平的影响

目的:探讨补充维生素A(VA)对强化接种麻疹疫苗的学龄儿童产生的麻疹IgG抗体的影响。方法:选珠三角地区某市山区105名小学生,其中53名为补充组,另52名年龄、性别相匹配的儿童作为对照组,两组均接种麻疹疫苗,补充组儿童在接种疫苗的当天开始服用VA(2500IU/d),连续口服1个月,应用高效液相色谱(HPLC)法测定补充前后和对照组血清中VA含量。用酶联免疫吸附试验(ELISA)间接法测定接种前后麻疹特异性IgG抗体。结果:补充组血清中VA显著升高,为376.5±74.2μg/L,两组接种麻疹疫苗一个月后,VA补充组抗体阳性率由69.8%上升至100.0%,保护率由5.6%上升至60.4%;对照组阳性率由71.2%上升至100.0%,保护率由0%上升为17.4%。麻疹免疫之后,两组的抗体阳性率都大大升高,但VA补充组的保护率比对照组升高明显。结论:补充维生素A对接种麻疹疫苗的学龄儿童(特别是缺乏VA的儿童)所产生的抗体水平升高起到明显的促进作用。

EFFECT OF VITAMIN A SUPPLEMENTATION ON THE LEVEL OF IgG ANTIBODY TO MEASLES STRENGTHENED VACCINATION

Objective: To study the relationship between vitamin A (VA) supplementation and the level of IgG antibody to measles strengthened vaccination. Method: Fifty-three school children aged 5-13 years were selected as the test group of VA supplementation, and fifty-two school children as the control group whose ages and sex matched with the test group. The test group was supplicd po the VA pills (2 500IU) at the same time with measles strengthened vaccination for one month. The level of serum VA was analyzed by HPLC. Measles antibody IgG was detected by ELISA. Results: One month after VA supplementation, sernm VA in test group was 376.5±74.2 μg/L, showing statistical increase over before. The positive rates of measles antibody in the test group were increased from 69.8% to 100%, and the protective rate from 5.6% to 60.4%. The positive rates of measles antibody in the control group were increased from 71.2% to 100%, and the protective rates from 0% to 17.4%. The protective rate in the test group was statistically higher than the control. Conclusion: Simultaneous VA supplementation (especially for the children of VA deficiency) and measles strengthened vaccination contribute to the increase of measles antibody IgG in school children.