Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli |
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| Authors: | Lehtopolku Mirva Kotilainen Pirkko Haanperä-Heikkinen Marjo Nakari Ulla-Maija Hänninen Marja-Liisa Huovinen Pentti Siitonen Anja Eerola Erkki Jalava Jari Hakanen Antti J |
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| Affiliation: | Antimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland. mipleht@utu.fi |
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| Abstract: | The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species. |
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