CD44与肝细胞癌的分化和血管浸润

目的:了解在肝细胞癌的表达及其与瘤组织的分化和血管浸润的关系。CD44方法:用免疫组化方法对例人体肝67癌组织做和检测,其中例伴肝内血管浸润,例伴癌旁非癌肝组织。CD44sCD44v61547结果:例肝癌组织阳性14CD44s(,),与癌旁肝组织(,)无显著差异(14/6720.90%5/4710.64%P>)。例肝癌组织阳性(,0.0518CD44v618/67),与癌旁肝组织()有明显差异(26.87%0/47P<)。二者表达均与肿瘤分化和血管浸润无关(0.01P>)。0.05结论:肝细胞癌的高表达较有意义。两者与肿瘤的分化和肝内血管浸润无关。CD44v6CD44s

The observation of CD44 on differentiation and vascular invasion in hepatocellular carcinoma

Objective: The purpose of the experiment is to examine the expressions of CD44 on hepatocellular carcinomas and to study the effects on the differentiation and vascular invasion. Methods: Sixty-seven specimens of hepatocellular carcinoma were obtained from surgical excisions (15 cases with intrahepatic vascular invasions and 47 with both cancerous and non-cancerous liver tissue). Immunohistochemical stainings of CD44s and CD44v6 were performed, and SPSS software was applied for statistical analysis. Results: Fourteen cases were (,)(,)CD44s positive in the tumor tissues14/6720.90%and CD44v6 positive in 18 cases 18/6726.87%. (Both expressions correlated with neither tumor cell differentiation nor vascular invasionP>)0.05. Compared (with the non-cancerous liver tissue, CD44v6 was significantly differentP<)0.01. Conclusion: The overexpression of CD44v6 in hepatocellular carcinoma is more significant than that of CD44s. However, they were not correlated with differentiation and intrahepatic vascular invasion.