Hyperosmotic arabinose solutions open the tight junctions between brain capillary endothelial cells in tissue culture |
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| Authors: | Katerina Dorovini-Zis Phillip D Bowman A Lorris Betz Gary W Goldstein |
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| Institution: | 1. Department of Pathology (Neuropathology), University of Michigan, Ann Arbor, MI 48109 U.S.A.;2. Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 U.S.A.;3. Department of Neurology, University of Michigan, Ann Arbor, MI 48109 U.S.A. |
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| Abstract: | Noradrenergic, serotoninergic and peptidergic nerves have been demonstrated in perivascular plexuses of vasa nervorum of sympathetic, parasympathetic and somatic nerve trunks. 5-Hydroxytryptamine-, vasoactive intestinal polypeptide- and substance P-containing fibers were found by immunohistochemistry to variable extents in whole mounts of the epineurium of sciatic, vagus and paravertebral sympathetic chains of rabbits. Innervation increased with age. This suggests an hitherto unsuspected role for these vasoactive substances in normal blood flow to nerves and in the genesis of experimental and human neuropathies. |
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| Keywords: | brain capillary endothelium tight junctions arabinose horseradish peroxidase |
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