卵巢癌组织中脂肪酸合成酶的表达及其临床意义

目的探讨脂肪酸合成酶（FAS）在卵巢上皮性肿瘤组织中的表达及临床病理意义。方法免疫组化方法检测38例卵巢浆液性腺癌、32例非卵巢浆液性腺癌（15例卵巢黏液性腺癌,17例子宫内膜样腺癌）、14例卵巢交界性肿瘤、16例卵巢良性组织、20例正常卵巢组织中FAS的表达情况,结合临床病理特征进行统计学分析。结果 FAS在卵巢癌组织中呈高表达,而在卵巢良性肿瘤及正常卵巢组织中仅少量表达或无表达,差异有统计学意义（P〈0.05）。与临床分期,组织分化及淋巴结转移之间存在相关性。结论 FAS的表达可能与卵巢上皮性癌的发生、发展密切相关,FAS可望作为卵巢上皮癌治疗的一个新靶点。

Expression of fatty acid synthase in ovarian epithelial carcinoma and its clinical significance

Objective To investigate the expression and significant of fatty acid synthase （FAS） in human epithelial ovarian cancer （EOC）. Methods Immunohistochemieal methods was employed to detect the expression of FAS in the human EOC, normal hu- man ovarian tissue and benign tumor,including 70 EOC tissues and 14 ovarian borderline epithelial tumors, 16 ovary benign tumors,20 normal ovarian tissue sections, and its relationship with pathology parameter was analyzed. Results The expression of FAS protein was significantly higher in the human EOC than that of normal tissues, and was correlated with stages of lymph node metastasis and pathologi- cal grades. Conclusion FAS protein plays an important role in pathogenesis and development of cervical carcinoma, and indicating that it may act as a promising biomarker for predicting EOC progression and as a potential target for diagnosis and therapy.