| JAK-STAT信号通路与结直肠癌 |
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| 引用本文： | 李文英,陈萦晅,房静远. JAK-STAT信号通路与结直肠癌[J]. 国际消化病杂志, 2009, 29(1) |
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| 作者姓名： | 李文英 陈萦晅 房静远 |
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| 作者单位： | 200001,上海交通大学医学院附属仁济医院;200001,上海市消化疾病研究所;200001,上海交通大学医学院附属仁济医院;200001,上海市消化疾病研究所;200001,上海交通大学医学院附属仁济医院;200001,上海市消化疾病研究所 |
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| 摘 要： | 结直肠癌是一种常见的恶性肿瘤,它的发生是一个复杂多阶段的过程,涉及肠上皮细胞的增殖、凋亡、分化和生存等机制.近来研究发现JAK-STAT信号通路的异常活化与结直肠癌的关系密切,涉及结直肠癌的发生、发展、侵袭、转移和预后等过程.因此,JAK-STAT信号通路有可能成为结直肠癌治疗的新靶点.
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| 关 键 词： | 结直肠癌 JAK-STAT STAT3 肿瘤 |
Jak-Stat signaling pathways and colorectal cancer |
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| LI Wen-ying,CHEN Ying-xuan,FANG Jing-yuan. Jak-Stat signaling pathways and colorectal cancer[J]. International Journal of Digestive Disease, 2009, 29(1) |
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| Authors: | LI Wen-ying CHEN Ying-xuan FANG Jing-yuan |
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| Abstract: | Colorectal cancer is one of the most common malignancies.Colorectal carcinogenesis is a complex multistep process involving progressive disruption of intestinal epithelial-cell proliferation,apoptosis,differentiation,and survival mechanisms.Currently,accumulating evidence indicates that abnormalities in the JAK-STAT pathway is involved in the pathogenesis,progression,metastasis and prognosis of human colorectal cancer.Thus,the JAK-STAT pathway may be a new potential target for therapy of colorectal cancer. |
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| Keywords: | JAK-STAT STAT3 |
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