| 锌酞菁－LDL复合物光敏作用诱导小鼠肿瘤细胞程序性死亡 |
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| 引用本文： | 周传农,池顺姬,邓津生,梁军林. 锌酞菁－LDL复合物光敏作用诱导小鼠肿瘤细胞程序性死亡[J]. 中国医学科学院学报, 1995, 0(1) |
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| 作者姓名： | 周传农 池顺姬 邓津生 梁军林 |
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| 作者单位： | 中国医学科学院，中国协和医科大学肿瘤研究所 |
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| 摘 要： | 电镜观察表明，锌酞菁人血清低密度脂蛋白（ＬＤＬ）复合物对小鼠ＭＳ－２纤维肉瘤细胞有很强的直接光敏杀伤作用，瘤细胞出现一系列结构改变：核染色质凝聚、局部核膜孔消失、核固缩、核破裂、凝聚的染色质流散、胞质内吞噬现象、胞膜表面肿胀粗钝的胞突形成、细胞碎裂等。提示该复合物光敏作用可诱导肿瘤细胞的程序性死亡，为解释其光敏杀伤机理提供了新的论据。
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| 关 键 词： | 锌酞菁，光化学疗法，纤维肉瘤 |
Apoptosis of Mouse MSD-2 Fibrosarcoma Cells Induced by Photodynamic Therapy with LDL-administered Zinc-phthalocyanine |
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| Zhou Chuannong,Chi Shunji,Deng Jinsheng Liang Junlin, Biolo Roberta,et al. Apoptosis of Mouse MSD-2 Fibrosarcoma Cells Induced by Photodynamic Therapy with LDL-administered Zinc-phthalocyanine[J]. Acta Academiae Medicinae Sinicae, 1995, 0(1) |
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| Authors: | Zhou Chuannong Chi Shunji Deng Jinsheng Liang Junlin Biolo Roberta et al |
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| Abstract: | Phthalocyanine destruction of MS-2 fibrosarcoma cells in mice induced by LDL-administered Zinc-phthalocyanine and red light irradiation was studied by electron microscopy.The pronounced structural changes such as chromatin condensation,disappearance of nuclear pores,karyopyknosis,karyorrhexis,leakage of chromatin aggregates,autophagocytosis, bleb formation on the cell surface, cytoplasmic vacuolization and cell fragmentation suggest that the tumor cell death was induced by apoptosis.However,its exact mechanism and regulating pathways remain to be further investigated. |
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| Keywords: | zinc-phthalocyanine photochemotherapy fibrosarcoma |
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