The rapid efficacy of abatacept in a patient with rheumatoid vasculitis |
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Authors: | Fujii Wataru Kohno Masataka Ishino Hidetaka Nakabayashi Amane Fujioka Kazuki Kida Takashi Nagahara Hidetake Murakami Ken Nakamura Kaoru Seno Takahiro Yamamoto Aihiro Kawahito Yutaka |
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Institution: | Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan. |
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Abstract: | We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept. |
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