| 那格列奈治疗2型糖尿病的临床研究 |
| |
| 引用本文： | 徐浣白,石建华,张晓梅,陈凤玲,于磊.那格列奈治疗2型糖尿病的临床研究[J].蚌埠医学院学报,2005,30(3):237-239. |
| |
| 作者姓名： | 徐浣白 石建华 张晓梅 陈凤玲 于磊 |
| |
| 作者单位： | 蚌埠医学院附属医院内分泌科, 安徽蚌埠 233004 |
| |
| 摘 要： | 目的: 探讨那格列奈治疗2型糖尿病的有效性及安全性。方法: 采用随机、双盲双模拟、那格列奈与瑞格列奈(1:1)平行对照,整个试验过程12周。入选48例患者分为:试验组(那格列奈)24例和对照组(瑞格列奈)24例,治疗期间主要观察餐后2h血糖(2hPG)及糖化血红蛋白(HbAlc)水平。结果: 两组患者2hPG及HbAlc治疗后均较治疗前下降(P<0.01),改善值两组间差异均无显著性(P>0.05)。结论: 那格列奈能有效降低2型糖尿病患者的2hPG和HbAlc,降糖效果好,不良反应(尤其是低血糖)少且程度较轻,患者有良好的依从性及耐受性。
|
| 关 键 词： | 2型糖尿病 那格列奈 血糖 糖化血红蛋白 |
| 文章编号： | 1000-2200(2005)03-0237-03 |
| 收稿时间： | 2004-09-09 |
| 修稿时间： | 2004年9月9日 |
Nateglinide in treatment of type 2 diabetes |
| |
| XU Huan-bai,SHI Jian-hua,ZHANG Xiao-mei,CHEN Feng-ling,YU Lei.Nateglinide in treatment of type 2 diabetes[J].Journal of Bengbu Medical College,2005,30(3):237-239. |
| |
| Authors: | XU Huan-bai SHI Jian-hua ZHANG Xiao-mei CHEN Feng-ling YU Lei |
| |
| Institution: | Department of Endocrineology, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China |
| |
| Abstract: | Objective:To investigate the effect and safety of nateglinide in treatment of patients with type 2 diabetes mellitus.Methods:A randomized double blind control trial was followed up for twelve weeks.Forty-eight selected cases were randomly divided into two groups in the ratio of one to one:observation group (nateglinide) and control group (repaglinide).The 2 hours plasma glucose(2hPG) and HbAlc levels of the patients were observed.Results:2hPG and HbAlc levels of the two groups decreased obviously after treatment(P<(0.01)).The decreasing levels of 2hPG and HbAlc of each group' had no obvious differences (P>0.05).Conclusions:Nateglinide is effective and safe for the treatment of type 2 diabetes mellitus with slight side effects. |
| |
| Keywords: | diabetes mellitus non-insulin-dependent nateglinide blood glucose HbAlc |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 |
| 点击此处可从《蚌埠医学院学报》下载免费的PDF全文 |
