| 野菊花栓的长期毒性试验 |
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| 引用本文： | 韦桂宁,周军,周桂芬,何飞. 野菊花栓的长期毒性试验[J]. 中国药师, 2009, 12(2) |
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| 作者姓名： | 韦桂宁 周军 周桂芬 何飞 |
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| 作者单位： | 广西中医药研究院,南宁,530022 |
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| 摘 要： | 目的:观察野菊花栓长期给药对大鼠产生的毒性反应。方法:100只wistar大鼠随机分为大、中、小剂量组,赋型剂组及正常对照组,大、中、小剂量组各20只,分别给予野菊花栓浸膏20g原药材/kg、10g原药材/kg和5g原药材/kg,赋型剂组及正常对照组各20只,分别给予相同体积的60%的PEG混悬液和蒸馏水。各组连续直肠给药3个月后进行血液学、血液生化、脏器重量系数、组织病理学检查及常规观察。结果:给药组动物的外观行为,体重,脏器系数,血液学和血液生化学指标,与正常对照组比较,均无明显差异;病理检查未见与药物毒性相关的明显病变,停药后也未见药物延迟性毒性反应。结论:野菊花栓长期用药对大鼠无明显毒性,推断临床拟用剂量应是安全的。
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| 关 键 词： | 野菊花栓 长期毒性 大鼠直肠 |
Long-term Toxicity of Fins Chrysanthemi Indici Suppository in Rats |
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| Wei Guining,Zhou jun,Zhou Guifen,He Fei. Long-term Toxicity of Fins Chrysanthemi Indici Suppository in Rats[J]. China Pharmacist, 2009, 12(2) |
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| Authors: | Wei Guining Zhou jun Zhou Guifen He Fei |
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| Affiliation: | Wei Guining; Zhou jun; Zhou Guifen; He Fei(Guangxi Institute of Traeditional Chinese Medicine & Pharmaceutical Science; Nanning 530022; China); |
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| Abstract: | Objective:To observe the long-term toxicity of flos chrysanthemi indici suppository in rats.Method:One hundren Wistar rats were randomly divided into 5 groups,All the low,medium and high dose groups consisted of 20 rats were rectum given flos chrysanthemi indici suppository at dose of 20g·kg·d~(-1),10g·kg·d~(-1) and 5g·kg·d~(-1) Chinese herb,respectively.20 rats of the excipients group were each equivalent volume of 60%PEG suspension,and 20 rats of the control group were each equivalent volume of still wate... |
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| Keywords: | Flos Chrysanthemi Indici Yejuhua Suppository Long term toxicity Rectum of rat |
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