Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction |
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| Authors: | Savas Murat Yeni Ercan Verit Ayhan Gulum Mehmet Aksoy Nurten Ciftci Halil Celik Hakim Altunkol Adem Oncel Halil |
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| Institution: | IHarran University, School of Medicine, Department of Urology, Sanliurfa, Turkey. ;IIHarran University, School of Medicine, Department of Clinical Biochemistry, Sanliurfa, Turkey. ;IIISanliurfa Research Hospital, Department of Urology, Sanliurfa, Turkey. |
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| Abstract: | OBJECTIVES:To investigate the acute effect of phosphodiesterase type 5 (PDE5) inhibitor on erectile dysfunction by evaluating serum oxidative status and prolidase activity.METHODS:Serum samples of 36 patients with erectile dysfunction and 30 control cases were analyzed for total antioxidant status, total oxidant status, and prolidase activity, before and after the administration of tadalafil citrate.RESULTS:Before and after tadalafil citrate administration, serum total antioxidant status, total oxidant status, and prolidase were 1.1±0.0 vs. 1.6±0.0 µmol H2O2 Eq/L, 10.3±1.1 vs. 6.9±1.2 µmol H2O2 Eq/L, and 236.4±19.5 vs. 228.2±19.2 U/L, respectively (p<0.0001 for all).CONCLUSIONS:Evaluation of serum oxidative status and prolidase activity confirmed the beneficial acute effects of PDE5 inhibitor in patients with erectile dysfunction. |
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| Keywords: | Phosphodiesterase type 5 inhibitors Tadalafil citrate Total antioxidant status Total oxidant status Prolidase |
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