Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry |
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| Authors: | Robles Francisco E Zhu Yizheng Lee Jin Sharma Sheela Wax Adam |
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| Affiliation: | 1Department of Biomedical Engineering and Fitzpatrick Institute for Photonics,
Duke University, Durham NC 27708, USA;2Medical Physics Program, Duke University, Durham NC 27708, USA;3The Hamner Institutes for Health, Research Triangle Park, NC 27709, USA |
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| Abstract: | Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated with colorectal cancer development. |
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