| 乙型肝炎病毒相关性肾炎α-干扰素治疗后的病理变化 |
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| 引用本文： | 郑新华,段尚林,王仲倩,段新科,周飞. 乙型肝炎病毒相关性肾炎α-干扰素治疗后的病理变化[J]. 实用医药杂志(山东), 2004, 21(7): 587-588 |
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| 作者姓名： | 郑新华 段尚林 王仲倩 段新科 周飞 |
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| 作者单位： | 平顶山卫生学校病理学教研室，152医院，152医院，152医院，复旦大学中西医教研室 河南平顶山467001，河南平顶山467001，河南平顶山467001，上海200000 |
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| 摘 要： | 目的探讨乙型肝炎病毒相关性肾炎经α-干扰素治疗的临床病理变化。方法32例HBV相关性肾炎给予α-干扰素100～300万U,肌肉注射,6个月为一疗程,比较治疗前后血清白蛋白浓度,24h尿蛋白定量及肾组织乙肝抗原、HBV-DNA、IgG、IgM、IgA阳性率。结果α-干扰素治疗后血清白蛋白浓度升高、尿蛋白定量下降;肾组织乙肝抗原、HBV-DNA、IgA、IgM、IgG阳性率均显著下降(P<0.01)。结论乙型肝炎病毒相关性肾炎经α-干扰素治疗后临床病理有较显著改善。
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| 关 键 词： | 乙型肝炎病毒 肾小球肾炎 病理 α-干扰素 |
| 修稿时间： | 2004-03-08 |
The clinical pathologic changes of hepatitis B virus associated glomerulonephritis follow alpha interferon |
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| Abstract: | Objective To study the clinical pathologic changes of hepatitis B virus associated glomerulonephritis follow alpha interferon.Methods Thirty two patients with hepatitis B virus associated glomerulonephritis received alpha interferon.Later six months after the therapy the difference between pre-and post-treatment in albumin,24h-urinary protein,and the positive rates of HBAg,HBV-DNA,IgG,IgM,IgA in the renal tissue were compared.Result After the alpha interferon therapy,the albumin increased,and the24h-urinary protein decreased,all the positive rates above also decreased significantly.Conclusion Alpha interferon is effective in HBV associated glomerulonephritis either in cliniclc or in pathology. |
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| Keywords: | Hepatitis B virus Glomerulonephritis Pathology Alpha interferon |
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