大动脉僵硬度与冠脉病变严重性的相关研究

目的:探讨大动脉僵硬度与冠脉病变严重程度的相关性。方法:选择2006年1月—2007年12月疑诊为冠心病入院患者637例,所有入选患者均进行颈股脉搏波传导速度(C-FPWV)检测,评价动脉僵硬度。行冠脉造影评价冠脉病变严重程度。根据C-FPWV水平分为三组:组(C-FPWV0～10.0,220例),组(C-FPWV10.1～13.0,242例),组(C-FPWV≥13.1,175例),观察患者临床特征。结果:各组间比较,组年龄偏大,糖尿病,心肌梗死和高血压病史多,C型病变和三支病变常见,多因素Logistic分析冠脉病变严重程度和C-FPWV呈正相关联,相对危险性(OR)为1.51(95%CI 1.017～2.241)。结论:C-FPWV是最为经典的评价动脉僵硬度的方法,与冠脉病变的严重程度密切相关,可作为心血管疾病的一个危险信号,指导早期干预,为心血管疾病独立强有力预测因子,对冠心病防治有广泛应用前景。

The value of large artery stiffness in risk stratification outcomes evaluation in patients who received percutaneous coronary intervention

Objective:To evaluate the relationship between large artery stiffness and the severity degree of coronary atherosclerosis in patients who received coronary arteriography.Methods:We studied 637 consecutive patients who received coronary arteriography carotid-femoral puise wave velocity(C-FPWV) to evaluate large artery stiffness were measured.The severity degree of coronary atherosclerosis was shown as the score of coronary artery.According to C-FPWV they were divided into the following groups:Ⅰgroup(C-PPWV 0～10.0,220 patients),Ⅱgroup(C-FPWV 10.1～13.0,242 patients),Ⅲgroup(C-FPWV≥13.1,175 patients).The clinical characteristics were analyzed.Results:The percentage of older patients,diabetes,hypertension,myocardial infarction,type C lesion,three artery and the score of coronary artery were higher in Ⅲgroup compared other groups(P<0.05).Multi-logistic analysis showed that C-FPWV was positively related to the severity of coronary artery stenosis.OR was 1.51(95% CI 1.017～2.241).Conclusion:C-FPWV was the most classical method reflecting large artery stiffness and closely related to the severity of coronary artery stenosis.It could be a strong and independent factor of risk stratification outcomes evaluation and prognosis in patients who received coronary vascular disease.It should be applied widely to prevention and cure of coronary vascular disease.