| 大鼠脂联素和脂联素受体R2 mRNA表达水平和与胰岛素抵抗 |
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| 引用本文： | 杨春梅,徐焱成,成兴波.大鼠脂联素和脂联素受体R2 mRNA表达水平和与胰岛素抵抗[J].江苏医药,2008,34(7):715-717. |
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| 作者姓名： | 杨春梅 徐焱成 成兴波 |
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| 作者单位： | 1. 苏州大学附属第一医院内分泌病科,215006
2. 武汉大学中南医院内分泌病科 |
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| 摘 要： | 目的 研究脂联素及脂联素受体R2 mRNA水平与胰岛素抵抗的关系.方法 普通级雄性Wistar大鼠24只,随机分为高糖高脂组(A组)、罗格列酮组(B组)和正常对照组(C组).检测空腹血糖、空腹胰岛素和胰岛素抵抗指数(HOMA-IR);应用RT-PCR方法测定大鼠肝组织脂联素受体R2 mRNA的表达;ELISA法测定血浆脂联素水平.结果 与C组相比,A组脂联素及脂联素受体R2 mRNA水平均显著降低(P<0.05);B组的脂联素及其受体水平较高糖高脂组有所升高,但仅脂联素的升高差异有显著性(P<0.05);脂联素受体R2 mRNA与HOMA-IR负相关(r=-0.652,P<0.01).结论 脂联素参与胰岛素抵抗的发生,脂联素受体R2可能介导了该效应.
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| 关 键 词： | 脂联素 脂联素受体R2 胰岛素抵抗 |
Expression of adiponectin,adiponectin receptor R2 mRNA and insulin resistance in rats |
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| YANG Chunmei,XU Yancheng,CHENG Xingbo.Expression of adiponectin,adiponectin receptor R2 mRNA and insulin resistance in rats[J].Jiangsu Medical Journal,2008,34(7):715-717. |
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| Authors: | YANG Chunmei XU Yancheng CHENG Xingbo |
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| Institution: | YANG Chunmei,XU Yancheng,CHENG Xingbo.Department of Endocrinology,Affiliated First Hospital,Soochow University,Suzhou 215006,CHINA |
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| Abstract: | Objective To study the relationship of the expression of adiponectin and adiponectin receptor R2 mRNA and insulin resistance.Methods Twenty-four male Wistar rats were randomly divided into 3 groups of high fat and sugar (group A),rosiglitazone moleate (group B) and control group (group C) after weighting. All rats were killed after fasting for 12 h and the body weight was recorded at the end. Fasting blood glucose and insulin were measured and insulin resistance value (HOMA-IR) was assessed by homeostasis m... |
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| Keywords: | Adiponectin Adiponectin receptor R2 Insulin resistance |
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