| 内质网应激与神经元退行性变 |
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| 引用本文： | 冯利杰,王海萍,沈玉先. 内质网应激与神经元退行性变[J]. 中国药理学通报, 2007, 23(4): 428-432 |
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| 作者姓名： | 冯利杰 王海萍 沈玉先 |
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| 作者单位： | 1. 安徽医科大学临床药理研究所;教育部"重要遗传疾病基因资源利用"重点实验室省部共建
2. 安徽医科大学神经生物研究所,安徽,合肥,230032 |
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| 基金项目： | 国家自然科学基金;教育部跨世纪优秀人才培养计划 |
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| 摘 要： | 内质网(endoplasmic reticulum,ER)是蛋白质修饰、折叠和钙贮存的场所。ER内未折叠或错折叠蛋白积聚和钙平衡失调均可导致ER应激。早期的ER应激或未折叠蛋白反应,是一种自身代偿过程,对细胞起到保护作用,而长期、严重的ER应激则会诱导细胞凋亡及死亡。研究发现,ER应激在许多神经退行性疾病的病理机制中起重要作用。然而,确切的机制目前仍不清楚。该文就ER应激在神经元退行性变中的作用作一综述。
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| 关 键 词： | 内质网应激 神经退行性疾病 未折叠蛋白反应 细胞凋亡 |
| 文章编号： | 1001-1978（2007）04-0428-05 |
| 修稿时间： | 2006-10-12 |
ER stress involves in neuronal degeneration |
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| FENG Li-jie,WANG Hai-ping,SHEN Yu-xian. ER stress involves in neuronal degeneration[J]. Chinese Pharmacological Bulletin, 2007, 23(4): 428-432 |
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| Authors: | FENG Li-jie WANG Hai-ping SHEN Yu-xian |
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| Affiliation: | 1. Institute of Clinical Pharmacology,Anhui Medical University,2. The Key Laboratory of Gene Resource Utilization for Severe Diseases ,Ministry of Education,3. Institute of neurobiology,Anhui Medical University,Hefei 230032, China |
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| Abstract: | Endoplasmic reticulum(ER) is a locus where proteins are modified,folded and calcium stored.The accumulation of unfolded protein and disorder of calcium ion can lead to ER stress.Early ER stress will induce unfolded protein response(UPR)which may be protective to cells.On the contrary,long-time strong ER stress will induce cell apoptosis,even death.ER stress has been suggested to be involved in some human neurodegenerative diseases.However,the exact contributions of ER stress in the various disease processes are yet unknown.This review mainly summarizes recently reported discoveries concerning ER stress associated with neurodegenerative diseases and highlights current knowledge in this field that may reveal novel insight into disease mechanisms and help to design better therapies for these disorders. |
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| Keywords: | endoplasmic reticulum stress neurodegenerative disease unfolded protein response apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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