超高分子聚乳酸植入对大鼠的慢性毒性研究

目的观察超高分子聚乳酸在生物体内降解时，对动物是否有毒性及其他不良作用。方法将超高分子聚乳酸植入到SD大鼠体内，术后分批采取血液标本，对其蛋白含量、胆红素含量、脂类含量及重要的酶及电解质的情况进行检测，并采取植入区组织行常规组织学检查。结果超高分子聚乳酸植入到SD大鼠体内后，在术后3月、6月、9月和1年，实验组和对照组的血清白蛋白、球蛋白、总胆红素、结合胆红素、甘油三酯、血糖、钾、钠、氯、钙、碱性磷酸酶、谷丙脱氢酶均在正常范围内，实验组较对照组之间无统计学差异。实验组较对照组乳酸脱氢酶轻度升高，但无统计学差异。光镜下各时段植入区组织未见不可逆的排斥反应。结论超高分子聚乳酸长期植入到动物体内后，对动物无毒性及不良作用。

Study on Chronic Toxicity to Rats of Implantation of Super-high Molecular Weight Polylactate

Objective To make sure whether super-high molecular weight polylactate is toxic to the body after it has been implanted into the body for a long period. Methods We implanted super-high molecular weight polylactate into the rats and took the specimens of blood at 3, 6, 9, 12 months after the operation. The changes of proteins, electrolyte, enzyme and other indices were observed. At the same time, the tissue around the implants were taken out to carry out the histological observation. Results At 3, 6, 9, 12 months after the operation, the levels of albumin, globulin, total bilirubin, direct bilirubin, triglyceride, glucose, K+, Na+, Cl-, Ca 2+, alkaline phosphatase, glutamic-pyruvic transaminase in the blood plasma were all in the normal range; there were no significant differences between the experimental group and the control group. The level of lactate dehydrogenase increased slightly, but there was no statistically significant difference between the experimental group and the control group. There were no non-reversible immune rejection around the implants in the histological observation.Conclusion Super-high molecular weight polylactate is not toxic to the body after it has been implanted into the animals for a long period.