HIV感染者第二受体CCR5和CXCR4表达与机会性感染的相关性

目的分析HIV感染者第二受体表达与机会性感染的相关性，为临床监测提供依据。方法45例HIV-1阳性者作为研究组，其中发生机会性感染16例，无机会性感染29例。正常对照11例。比较机会性感染与无机会性感染HIV各期第二受体CCR5、CXCR4在CD4^＋T、CD8^＋T细胞上的表达，并分析其与CD4^＋／CD8^＋比值的相关性。结果与对照组比较，机会性感染组CD4^＋／CCR5、CD8^＋／CCR5、CD8^＋T细胞明显升高（P〈0．05或P〈0．01），而CD4^＋／CXCR4、CD4^＋T细胞明显下降（P〈0．01）。机会性感染组CD8^＋／CCR5[（43．4±22．4）％]明显地高于无机会性感染组[（29．9±20．8）％，（P〈0．05）]，CD8^＋T细胞[（1095．6±476．7）×100／L]明显高于无机会性感染组[（773．3±464．0）×10^6／L，（P〈0．05）]。CD4^＋／CXCR4表达与CD4^＋／CD8^＋比值呈正相关（r=0．306，P〈0．05），CD8^＋／CCR5与CD8^＋呈正相关（r=0．432，P〈0．01）。结论HIV感染者第二受体CCR5表达增高，CD4^＋／CXCR4表达下降，机会性感染者第二受体CD8^＋／CCR5表达增高更为明显。检测第二受体CCR5、CXCR4有一定的临床价值，但第二受体检测仍需要结合CD4^＋T细胞动态检验，以提高监测价值。

RELATIONSHIP OF CCR5 AND CXCR4 EXPRESSION TO OPPORTUNISTIC INFECTION IN HIV-INFECTED PATIENTS

Objective To analyze the relationship of CCR5 and CXCR4 expression to opportunistic infection,so as to provide the basis for clinical monitoring.Methods Forty-five HIV-1 positive patients were studied,among which 11 were normal controls,16 with opportunistic infection,29 without opportunistic infection.At each stage,the expression of CCR5 and CXCR4 in CD4+ T and CD8+ T cells was measured in the group with opportunistic infection and the group without,and the relation to CD4+ /CD8+ ratio was studied.Results ...