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Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads
Authors:Negi Arvind S  Kumar J K  Luqman Suaib  Shanker Karuna  Gupta M M  Khanuja S P S
Affiliation:Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow, India. arvindcimap@rediffmail.com
Abstract:Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomolecules was reported in the scientific literature, only a few were potent against various types of liver damages. Of which, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have largely attracted the scientific community. This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads.
Keywords:hepatoprotective  andrographolide  neoandrographolide  curcumin  picroside  kutkoside  phyllanthin  hypophyllanthin  silymarin  glycyrrhizin
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