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Synthesis of the Gln1-facteur thymique serique and its evaluation with human E-rosette bioassay |
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| Authors: | D. Konopinska A. Kubik A. Lange I.Z. Siemion S. Ślopek |
| Affiliation: | 1. Institute of Chemistry, University of Wroclaw, 50–383 Wroclaw, Poland;2. Department of Clinical Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland |
| Abstract: | Synthesis of an analog of facteur thymique serique (FTS) containing a glutaminyl residue in position 1 of the peptide chain is described. Like the original FTS, Gln1-FTS is able to induce T cell markers on lymphocytes in vitro in a picogram dosage range. The human E-rosette bioassay was adopted for the evaluation of biological activity of Gln1-FTS. It was also shown that the latter method can be used to evaluate the presence of target cells for FTS activity in peripheral blood lymphocytes in humans. |
| Keywords: | FTS facteur thymic serique DCCI dicyclohexylcarbodiamine t.l.c. thin-layer chromatography DMF dimethylformamide NEM TEA triethylamine Tx mouse thymectomized mouse Az azathioprine SRBC sheep red blood cells RFC rosette-forming cells TFX thymus factor X ANA antinuclear antibodies RA rheumatoid arthritis MG myasthenia gravis SLE systemic lupus erythematosus |
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