| 2-(3,4-二甲氧基苯基)-3-甲基丁腈合成工艺的改进 |
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| 引用本文： | 黄维,郭丽,何泽超. 2-(3,4-二甲氧基苯基)-3-甲基丁腈合成工艺的改进[J]. 华西药学杂志, 2006, 21(1): 53-54 |
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| 作者姓名： | 黄维 郭丽 何泽超 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学化工学院,四川,成都,610065 |
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| 摘 要： | 目的合成2-(3,4-二甲氧基苯基)-3-甲基丁腈并进行工艺改进。方法以3,4-二甲氧基乙腈和2-溴丙烷为原料,筛选相转移催化剂,进行烃化反应得到目标物。结果以四丁基溴化铵为催化剂,收率为82%,产物结构经熔点和核磁共振氢谱确认。结论所改进的合成路线操作简单,适合工业化生产。
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| 关 键 词： | 3 4-二甲氧基苯乙腈 碳烃化反应 相转移催化剂 四丁基溴化铵 |
| 文章编号： | 1006-0103(2006)01-0053-02 |
| 收稿时间： | 2004-07-01 |
| 修稿时间： | 2004-07-01 |
The synthetic technology of 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile |
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| HUANG Wei,GUO Li,HE Ze-chao. The synthetic technology of 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile[J]. West China Journal of Pharmaceutical Sciences, 2006, 21(1): 53-54 |
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| Authors: | HUANG Wei GUO Li HE Ze-chao |
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| Affiliation: | 1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China ; 2. School of Chemistry Eng eering, Sichuan University, Chengdu 610065, China |
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| Abstract: | OBJECTIVE To synthesize 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile(1) and improve the synthetic process.METHODS(1) was synthesized by using 3,4-dimethoxyphenylacetonitrile(2) and 2-bromopropane as the starting material with selected PTC.RESULTS TEBA was used as the optimistic catalyzer with yield of 82%.Chemical structure of the product was confirmed by melting point and()~1HNMR.CONCLUSION The synthetic route of this method is suitable for industrial production. |
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| Keywords: | 3 4-dimethoxyphenylacetonitrile C-Alkylation PTC Phase transfer catalyzer Tetrabuthylammonium bromide |
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