| 卵巢癌危险因素的Meta分析 |
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| 引用本文： | 冯丹,刘佳丽,许崇安.卵巢癌危险因素的Meta分析[J].中华肿瘤防治杂志,2010,17(22). |
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| 作者姓名： | 冯丹 刘佳丽 许崇安 |
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| 作者单位： | 中国医科大学附属第四医院肿瘤内科,辽宁,沈阳,110032 |
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| 摘 要： | 目的:探讨卵巢癌发病的可能危险因素及致病机制.方法:计算机检索CBMdisc、CNKI、雏普及万方电子数据库,手工检索相关杂志.由2位评价者独立检索和提取资料并交叉核对,纳入研究卵巢癌危险因素的相关病例对照试验.Meta分析软件是Cochrane协作网提供的RevMan5.0.结果:共纳入病例对照试验9个,包括3 169例患者,其中病例组1 320例,对照组1 849例.Meta分析结果显示,初潮年龄、初产年龄、痛经史、不孕史、恶性肿瘤家族史、大便不规律史及负性生活事件是卵巢癌发病的危险因素;足月妊娠史、多孕史、多产史、哺乳史、多次流产吏、多次结婚史、避孕药服用史及宫内节育史是卵巢癌发病的保护性因素.结论:卵巢癌主要危险因素包括初潮年龄、初产年龄、痛经史、不孕史、恶性肿瘤家族史、大便不规律史及负性生活事件,足月妊娠史、多孕史、多产史、哺乳史、多次流产史、多次结婚史、避孕药服用史及宫内节育吏是卵巢癌发病的保护性因素.
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| 关 键 词： | 卵巢肿瘤 危险因素 病例对照试验 Meta分析 |
Meta-analysis of case-control trials on risk factors of ovarian neoplasm |
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| FENG Dan,LIU Jia-li,XU Chong-an.Meta-analysis of case-control trials on risk factors of ovarian neoplasm[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(22). |
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| Authors: | FENG Dan LIU Jia-li XU Chong-an |
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| Institution: | FENG Dan,LIU Jia-li,XU Chong-an Department of Oncology,Fourth Affiliated Hospital,China Medical University,Shenyang 110032,P.R.China |
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| Abstract: | OBJECTIVE:To investigate potential risk factors of ovarian neoplasm and their pathogenic mechanism.METHODS:Search the CBMDISC,CNKI,VIP and Wanfang database by computer retrieval.Relevant journals,conference papers,thesis and reference list for clinical controlled trials on risk factors of ovarian cancer were also searched by manual retrieval.Two reviewers independently assessed trial quality and extracted data.The Cochrane Collaboration's software RevMan 5.0 was used for meta-analysis.RESULTS:Nine studies i... |
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| Keywords: | ovarian neoplasm risk factors controlled clinical trials Meta-analysis |
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