| 急性骨髓型放射病合并周围神经损伤的机制及治疗 |
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| 引用本文： | 胡龙虎,崔哲,韩雪英,李晓霞,王艳,周晋,姜丽波. 急性骨髓型放射病合并周围神经损伤的机制及治疗[J]. 中国伤残医学, 2010, 18(5) |
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| 作者姓名： | 胡龙虎 崔哲 韩雪英 李晓霞 王艳 周晋 姜丽波 |
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| 作者单位： | 1. 哈尔滨医科大学附属第一医院血液科,黑龙江,哈尔滨,150001
2. 齐齐哈尔医学院第二附属医院血液科 |
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| 基金项目： | 黑龙江省教育厅课题项目 |
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| 摘 要： | 目的:探讨急性骨髓型放射病(ARS)合并周围神经(PN)损伤的发生机制和治疗方法。方法:观察ARS病人治疗前后周围神经的电生理变化和大鼠ARS合并周围神经损伤的病理及超微结构变化。结果:(1)照射后ARS病人PN传导速度轻度减低,经维生素B族治疗后,PN传导速度明显改善;(2)大鼠ARS合并周围神经损伤的基本病理变化为:滋养血管轻度扩张、充血,神经髓鞘轻度肿胀和轻度板层分离、部分脱髓鞘,神经元Nissl小体部分溶解、线粒体絮状变性;上述病理为轻度变化,照射后3天最明显,14天有所恢复,30天基本恢复正常。结论:ARS合并周围神经损伤的病理变化轻微,经维生素B族治疗后,其PN传导速度明显改善。
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| 关 键 词： | 急性放射病 骨髓 周围神经 病理 |
Mechanism and Treatment of Acute Radiation Sickness with Peripheral Nerve Injury |
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| HU Long-hu,CUI Zhe,HAN Xue-ying,et al.. Mechanism and Treatment of Acute Radiation Sickness with Peripheral Nerve Injury[J]. Chinese JOurnal of Trauma and Disability Medicine, 2010, 18(5) |
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| Authors: | HU Long-hu CUI Zhe HAN Xue-ying et al. |
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| Affiliation: | HU Long-hu,CUI Zhe,HAN Xue-ying,et al.(The First Clinical Hospital of Harbin Medical University,HeiLongjiang Harbin 150001,China) |
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| Abstract: | Objective:To explore the mechanism and treatment of acute radiation sickness(ARS) and peripheral nerve(PN) injury.Methods:Observe the electrophysiological changes of PN in ARS patients before and after therapy and pathology and microstructure variation in rats with ARS and PN injury.Results:1.Speed of PN conduction in APS patients were lightly lowered,and were improved obviously after Vitamine B treatment;2.Basic pathological changes in rats with ARS and PN injury were:Dilation and congestion of nourish vei... |
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| Keywords: | ARS Bone marrow PN Pathology |
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