无偿献血中手工血小板临床疗效探讨

目的探讨机采和手工分离血小板的临床疗效差异。方法输注机采血小板患者81例次为机采组,输注手工血小板制剂患者86例次为手工组,分别在输注前和输注后24h作外周血血小板计数,观察临床止血效果、有无输血反应发生,计算血小板计数增加校正指数（CCI）、血小板回升率（PPR）、输注无效率、输血反应发生率等指标。结果 CCI、PPR、止血率在两组间差异无统计学意义（P〉0.05）;输血反应发生率和输注无效率在两组间差异有统计学意义（P〈0.01）。结论手工血小板临床疗效接近机采血小板,临床可结合患者实际情况合理使用手工血小板。

Study on the clinical efficacy of hand-separated platelet in the blood donation

Objective To observe the clinical efficacy of platelet transfusion isolated by hand and apheresis.Methods The 167 patients who received platelet transfusion were investigated retrospectively and divided into apheresis platelet transfusion group and hand-separated platelet transfusion group.the CCI,the PPR,the incidence rate of post-transfusion refractoriness to platelets（PTR）and adverse reaction were observed and assayed at before transfusion and 24hours after transfusion.Results The difference was not significant（P0.05）between the two groups in the CCI,the PPR and the rate of stop bleeding.The difference was significant（P0.01）between the two groups in the blood transfusion responds an incidence rate and the PTR.Conclusion The clinical efficacy of hand-separated platelet is close to machine-separated platelet,combine disaster practical stutas reasonable applications hand-separated platelet.