成都地区中老年人群高尿酸血症与代谢综合征关系的研究

目的探讨成都地区中老年人群高尿酸血症与代谢综合征及其各组分间的关系。方法利用成都地区慢性病防治项目的现况调查资料,分析40岁及40岁以上中老年人群的资料,比较高尿酸血症与正常尿酸人群的代谢综合征各项指标的患病率,并进一步分析高尿酸血症与代谢综合征各项指标的相关性。结果该人群高尿酸血症的患病率为11.36%,其中男15.69%,女8.69%,男性明显高于女性（P〈0.01）;代谢综合征的患病率为25.34%,其中男25.86%,女25.02%,两性之间患病率差异无统计学意义（P=0.50）。与正常尿酸组比较,高尿酸血症组代谢综合征、肥胖、高血压、高血糖和血脂异常的患病率升高,代谢组分异常数目亦增多（P〈0.01）。多因素Logistic回归分析显示腹部肥胖、血压升高、高血糖、三酰甘油升高、高密度脂蛋白降低都是高尿酸血症的独立危险因素（P〈0.01）。结论成都地区中老年人群高尿酸血症和代谢综合征的患病率很高,高尿酸血症人群更易发生代谢综合征和代谢异常。尽早对社区人群进行高尿酸血症和代谢综合征筛查和研究,制定相关干预策略,对降低心血管疾病事件的发生和疾病负担具有重要意义。

Relationship between hyperuricemia and metabolic syndrome among the middle-aged and elderly in Chengdu area

Objective To study the relationship between hyperuricemia（HUA）,metabolic syndrome（MS） and its components among the middle-aged and elderly in Chengdu area.Methods A cross-sectional population-based survey for chronic diseases in Chengdu was performed in 2008.By analyzing the data of population aged 40～79years,we compared the prevalence of MS and its components between normal uric acid and HUA,and further analyzed the relation between HUA,MS and its components respectively.Results The prevalence of HUA among this population in Chengdu was 11.36%,and 15.69% in men,8.69% in women.The prevalence is higher in men than women（P0.01）.The prevalence of MS was 25.34%,and 25.86% in men,25.02% in women.And there is no significant difference between men and women（P=0.50）.Compared with normal serum uric acid,the prevalence of MS,obesity,hypertension,hyperglycemia and dyslipidemia were higher in HUA group.Moreover,more metabolic disorders were found in HUA group.Multivariate Logistic regression analysis showed that abdominal obesity,high blood pressure,hyperglycemia,elevated triglycerides,reduced high density lipoprotein are independent risk factors to HUA（P0.01）.Conclusion The HUA and MS are highly prevalent in the middle-aged and elderly population in Chengdu.People with HUA are more susceptible to MS and metabolic abnormalities.There is a great significance to reduce the incidence of cardiovascular disease and disease burden by screening and intervening HUA and MS in the community-dwelling people as soon as possible.