Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients |
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| Authors: | Andreas Hillenbrand Uwe Knippschild Manfred Weiss Hubert Schrezenmeier Doris Henne-Bruns Markus Huber-Lang Anna M Wolf |
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| Institution: | (1) Department of General-, Visceral-, and Transplantation Surgery, University Hospital of Ulm, Steinhoevelstr. 9, 89075 Ulm, Germany;(2) Department of Anesthesiology, University Hospital of Ulm, Steinhoevelstr. 9, 89075 Ulm, Germany;(3) Institute of Clinical Tranfusion Medicine and Immunogenetics, Helmholtzstr. 10;, D-89081 Ulm, Germany;(4) Department of Traumatology, Hand and Reconstructive Surgery, University Hospital of Ulm, Steinhoevelstr. 9, 89075 Ulm, Germany |
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| Abstract: | Background Hyperglycemia and insulin resistance frequently occur in critically ill and in morbidly obese (MO) patients. Both conditions
are associated with altered serum levels of cytokines and adipokines. In addition, obesity related alterations in adipokine
expression contribute to insulin resistance in metabolic syndrome. In this study we examined the serum adipocytokine profile
in critically ill patients, MO patients, and healthy blood donors. |
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