Sodium nonivamide acetate: A non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties |
| |
| Affiliation: | 1. Chia-Nan Junior Pharmaceutical School, Tainan, Taiwan, Republic of China;2. Department of Anesthesiology Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China;3. Department of Pharmacology, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China;4. Department of Pharmacology, College of Medicine, National Chung-Kung University, Tainan, Taiwan, Republic of China;1. Institute for Innovative Drug Design and Evaluation, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China;2. State Key Laboratory of Natural Medicines, Center of Drug Discovery, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu 210009, China;1. Institute of Chemical Engineering and Environmental Technology, Fuel Cell Systems Group, Graz University of Technology, NAWI Graz, Inffeldgasse 25C, 8010 Graz, Austria;2. Institute of Organic Chemistry, Graz University of Technology, NAWI Graz, Stremayrgasse 9, 8010 Graz, Austria;3. IC2MP, Université de Poitiers, 4, Rue Michel Brunet-B27 TSA-51106, 86073 Poitiers Cedex 09, France;1. Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677-1848, USA;2. Département de Chimie, Faculté des Sciences Exactes, Université des Frères Mentouri, Constantine, Route d’Aine El Bey, 25000, Constantine, Algeria;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt;4. Laboratoire de Synthèse Organique, Modélisation et Optimisation des Procèdes (LOMOP), Université Badji Mokhtar, Faculté des Sciences, Département de Chimie, 23000 Annaba, Algeria;5. National Center for Natural Products Research, School of Pharmacy, University of Mississippi University, MS, 38677, USA;6. Faculty of Chemistry, University of Opole, Pl. Kopernika 11, 45-040, Opole, Poland;7. Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyse Physico-Chimique et Biologique (VARENBIOMOL), Université des Frères Mentouri, Constantine, Route d’Aine El Bey 25000, Constantine, Algeria |
| |
| Abstract: | - 1.1. Bradykinin-induced vascular pain in conscious rats, hyperalgesia in the rat hind paw, rat hind paw edema induced by compound 48/80 and carrageenin and dye exudation induced by intraperitoneal injection of 0.7% acetic acid in mice were all inhibited by sodium nonivamide acetate (SNA).
- 2.2. Collagen and arachidonic acid-induced rabbit platelet aggregations were inhibited by SNA and capsaicin. In human platelet microsomes, prostaglandin E2 formation in arachidonic acid metabolite was not inhibited by SNA but was inhibited by capsaicin and indomethacin; thromboxane B2 formation and its synthetase activity were inhibited by SNA and capsaicin.
- 3.3. In the extracellular recording, SNA could not decrease the action potential amplitude of the vagus nerve.
- 4.4. The motor activity of mice induced by caffeine (1.0 mg/kg) was inhibited by SNA and capsaicin.
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
