Biology of tooth replacement in amniotes |
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| Authors: | John A Whitlock Joy M Richman |
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| Institution: | John A Whitlock (Department of 0ral Health Sciences, Faculty of Dentistry, Life Sciences Institute, University of British Columbia, Vancouver, Canada)； Joy M Richman (Department of 0ral Health Sciences, Faculty of Dentistry, Life Sciences Institute, University of British Columbia, Vancouver, Canada)； |
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| Abstract: | Tooth replacement is a common trait to most vertebrates, including mammals. Mammals, however, have lost the capacity for continuous tooth renewal seen in most other vertebrates, and typically have only 1–2 generations of teeth. Here, we review the mechanisms of tooth replacement in reptiles and mammals, and discuss in detail the current and historical theories on control of timing and pattern of tooth replacement and development. |
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| Keywords: | dental lamina growth factor signalling mammal epithelial stem cells diphyodonty polyphyodonty reptile successional lamina tooth replacement Zahnreihen zone of inhibition |
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